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Owing to their similar properties to the natural extracellular matrix (ECM) (high water content, porous structure, and biocompatibility) 14 , hydrogel scaffolds have been widely investigated in tissue engineering, in which injectable hydrogels with the potential for minimally invasive surgery and facile stem cells and drug loading capacities have been verified to have a positive effect on the stimulation of cartilage regeneration 15,16

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However, sustained ERK activation can contribute to fibrosis and hepatocellular carcinoma